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. 2024 Jun 14;17(6):1271–1280. doi: 10.14202/vetworld.2024.1271-1280

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Copyright: © Fotouh, et al.

Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Figure-1 — Liver from broilers administered azithromycin (Az) with escalating doses. (a) From control group showing normal hepatocytes (blue arrowhead) radiating around central vein (black arrowhead) (hematoxylin and eosin [H&E], scale bar: 200). (b) No positive reaction for caspases 3 (immunohistochemistry [IHC] stain, scale bar: 200). (c) From group Az 200 mg/kg at 3^rd-day post-treatment. Congestion and hemorrhage of sinusoids (black arrowhead), focal areas of coagulative necrosis (black arrow), and newly formed blood vessels (blue arrowhead) (H&E, scale bar: 200). (d) Strong positive reaction for caspases-3 in hepatocytes (black arrowhead) and bile ductal epithelium (black arrow) (IHC stain, scale bar: 50). (e) From group Az 200 mg/kg at 7^th-day post-treatment. Vacuolar degeneration allover hepatic parenchyma (black arrowhead) (H&E, scale bar: 200). (f) Mild positive reaction for caspases-3 in hepatocytes (black arrowhead) (IHC stain, scale bar: 50).