Table-6.

Prediction of absorption, distribution, metabolism, elimination, and toxicity of 17 secondary metabolites of Veitchia merrillii fruit seeds.

Compounds	Absorption		Distribution		Metabolism							Carcinogenic
	HIA (%)	Caco-2	Plasma protein binding (%)	blood brain barrier	3A4 substrate	2D6 substrate	1A2 inhibitor	C19 inhibitor	2C9 inhibitor	2D6 inhibitor	3A4 inhibitor
		Log (10−6cm/s)
Gallic aci	43.37	−0.081	38.3	−1.855	No	No	No	No	No	No	No	-
Pyrogallol	83.55	1.12	28.8	−0.441	No	No	No	No	No	No	No	-
Caffeic acid	69.41	0.634	38,7	−0.647	No	No	No	No	No	No	No	+
Vanillic acid	78.15	0.33	50.2	−0.38	No	No	No	No	No	No	No	-
Syringic acid	73.07	0.495	39.1	−0.191	No	No	No	No	No	No	No	-
Rutin	23.45	−0.949	81.3	−1.898	No	No	No	No	No	No	No	-
Naringenin	91.31	1.029	93.6	−0.578	No	No	Yes	No	No	No	No	-
Limonene	95.89	1.401	61.4	0.732	No	No	No	No	No	No	No	-
cis-β-ocimene	94.73	1.406	23.9	−1.848	No	No	No	No	No	No	No	-
Allo-ocimene	95.45	1.419	25.4	0.746	No	No	No	No	No	No	No	+
Linalool oxide	93.91	1.584	46	0.368	No	No	No	No	No	No	No	-
Linalool	93.16	1.493	51.6	0.598	No	No	No	No	No	No	No	-
Methyl salicylate	89.46	1.202	51	−0.222	No	No	No	No	No	No	No	-
Eucalyptol	96.51	1.485	44.7	0.368	No	No	No	No	No	No	No	-
Palmitic acid	92	1.558	89.9	−0.111	No	Yes	No	No	No	No	No	-
Oleic acid	91.82	1.563	94.8	−0.168	Yes	Yes	No	No	No	No	No	-
Linoleic acid	92.33	1.57	94.6	−0.142	Yes	Yes	No	No	No	No	No	-
Praziquantel	93.42	1.759	55.2	0.468	No	Yes	No	Yes	No	No	No	-