Table 3.
Matched-Pair dataset: outcomes of treatments according to the cause of infertility
| Outcome | Female factor | Unexplained factor | |||||
|---|---|---|---|---|---|---|---|
| IVF | ICSI | p | IVF | ICSI | p | ||
| Cycles | N | 13,992 | 13,992 | 30,573 | 30,573 | ||
| Fertilization rate* | Median (IQR) | 67% (50–83%) | 75% (57–88%) | < 0.001 | 67% (44–83%) | 73% (54–88%) | < 0.001 |
| Freeze all | N (%) | 520 (3.7%) | 821 (5.9%) | < 0.001 | 882 (2.9%) | 1384 (4.5%) | < 0.001 |
| No available embryos | N (%) | 865 (6.2%) | 561 (4.0%) | < 0.001 | 2335 (7.6%) | 1587 (5.2%) | < 0.001 |
| N of embryos transferred | Mean (SD) | 1.59 (0.52) | 1.59 (0.55) | 0.40 | 1.60 (0.54) | 1.59 (0.57) | 0.33 |
| 1 | N (%) | 5343 (38.2%) | 5568 (39.8%) | < 0.001 | 11,683 (38.2%) | 12,438 (40.7%) | < 0.001 |
| 2 | N (%) | 7070 (50.5%) | 6695 (47.8%) | 14,737 (48.2%) | 14,007 (45.8%) | ||
| 3 | N (%) | 194 (1.4%) | 347 (2.5%) | 718 (2.3%) | 1157 (3.8%) | ||
| Embryo transfer stage | |||||||
| Cleavage stage | N (%) | 8436 (66.9%) | 7160 (56.8%) | < 0.001 | 17,710 (65.3%) | 15,180 (55.0%) | < 0.001 |
| Blastocyst stage | N (%) | 4006 (31.8%) | 5222 (41.4%) | 9099 (33.5%) | 11,911 (43.2%) | ||
| Other/unspecified | N (%) | 165 (1.3%) | 228 (1.8%) | 329 (1.2%) | 511 (1.9%) | ||
| Cycles with ≥ 1 embryo stored | N (%) | 5064 (36.2%) | 5554 (39.7%) | < 0.001 | 9654 (31.6%) | 11,348 (37.1%) | < 0.001 |
| 1–5 embryos | N (%) | 4192 (30.0%) | 4397 (31.4%) | < 0.001 | 8102 (26.5%) | 9449 (30.9%) | < 0.001 |
| > 5 embryos | N (%) | 872 (6.2%) | 1157 (8.3%) | 1152 (5.1%) | 1899 (6.2%) | ||
| Pregnancies with FHB | N; % (95%CI) | 4479; 32.0% (31.2–32.8%) | 4616; 33.0% (32.2–33.8%) | 0.08 | 9303; 30.4% (29.9–31.0%) | 9743; 31.9% (31.4–32.4%) | < 0.001 |
| Implantation rate (with FHB) | |||||||
| Single embryo transfer | N Implanted/transferred | 1933/5343 | 2057/5568 | 0.41 | 4044/11683 | 4462/12438 | 0.041 |
| % (95%CI) | 36.2% (24.9–37.5%) | 36.9 (35.7–38.2%) | 34.6% (33.8–35.5%) | 35.9% (35.0–36.7%) | |||
| Double embryo transfer | N Implanted/transferred | 3299/14140 | 3287/13390 | 0.018 | 6561/29474 | 6379/28014 | 0.14 |
| % (95%CI) | 23.3% (22.6–24.0%) | 24.5% (23.8–25.3%) | 22.3% (21.8–22.7%) | 22.8% (22.3–23.3%) | |||
| Triple embryo transfer | N Implanted/transferred | 33/582 | 70/1041 | 0.40 | 166/2154 | 312/3471 | 0.09 |
| % (95%CI) | 6.0% (4.1–7.9%) | 6.7% (5.2–8.2%) | 7.7% (6.6–8.8%) | 9.0% (8.0–9.9%) | |||
| Live Birth Occurrence | N; % (95%CI) | 3992; 28.5% (27.8–29.3%) | 4029; 28.8% (28.1–29.6%) | 0.93 | 8120; 26.6% (26.1–27.1%) | 8479; 27.7% (27.2–28.2%) | 0.001 |
*cycles perfomed in 2017–2018 were excluded since the number of inseminated/fertilized oocytes are available as categorical data only
IVF, conventional in vitro insemination; ICSI, intracytoplasmic sperm injection; FHB, fetal heartbeat; IQR, interquartile range; SD, standard deviation; 95%CI, 95% confidence interval