Table 4.

Odds Ratios for main outcomes according to the cause of infertility in ICSI compared to IVF cycles

	Female factor		Unexplained factor
	Entire dataset	Matched-pair dataset	Entire dataset	Matched-pair dataset
Live birth/cycle
Crude OR	0.96 (0.92–1.00)	1.01 (0.96–1.07)	1.00 (0.97–1.03)	1.06 (1.02–1.10)
Adjusted OR*	0.95 (0.91–0.99)	0.91 (0.86–0.96)	0.98 (0.95–1.01)	0.97 (0.93–1.01)
Cycle cancellation
Crude OR	0.77 (0.70–0.85)	0.63 (0.57–0.71)	0.60 (0.55–0.64)	0.60 (0.56–0.64)
Adjusted OR*	0.72 (0.65–0.79)	0.66 (0.59–0.74)	0.72 (0.68–0.76)	0.64 (0.60–0.68)
Implantation
Crude OR	0.96 (0.92–0.99)	1.04 (1.00–1.10)	0.97 (0.95–1.00)	1.03 (1.00–1.06)
Adjusted OR**	0.92 (0.89–0.96)	0.92 (0.88–0.97)	0.93 (0.91–0.96)	0.93 (0.90–0.96)
Miscarriage
Crude OR	1.13 (1.02–1.24)	1.19 (1.05–1.35)	1.05 (0.98–1.13)	1.03 (0.95–1.12)
Adjusted OR**	1.12 (1.01–1.23)	1.24 (1.09–1.41)	1.08 (1.01–1.16)	1.09 (1.00–1.19)
Male sex in newborns (in single pregnancies)
Crude OR	0.84 (0.77–0.91)	0.86 (0.77–0.96)	0.86 (0.81–0.92)	0.88 (0.82–0.95)
Adjusted OR**	0.83 (0.77–0.91)	0.86 (0.77–0.96)	0.87 (0.81–0.92)	0.88 (0.81–0.95)

OR, Odds Ratio with 95% Confidence Intervals in brackets; IVF, conventional in vitro insemination; ICSI, intracytoplasmic sperm injection; Statistically significant results are indicated by confidence interval ranges that do not include the value 1 (p < 0.05)

^*Adjustment was performed including PCA1 (principal component analysis based on female age and number of inseminated oocytes), type of female factor, year of treatment

^**Adjustment was performed including PCA1 (principal component analysis based on female age, number of inseminated oocytes), PCA2 (number and stage of transferred embryos), type of female factor, year of treatment