Figure 2.

Cohort-specific artificial intelligence algorithm-derived probabilities of hypertrophic cardiomyopathy in (A) hypertrophic cardiomyopathy cases and (B) controls. The box plots show median, inter-quartile range, and max–min values of artificial intelligence scores. Optimal algorithm probability thresholds (based on the Youden index) for detecting hypertrophic cardiomyopathy status were as follows: combined cohort = 18%, Bern = 7%, Oxford = 4%, and Seoul = 18%. The optimal probability threshold in the algorithm’s derivation cohort from Mayo Clinic was 11%.