Figure 4.

Correlation patterns of the distinctive gut microbial genera and the renal dysfunction. BMI, body mass index; CREA, creatinine, DKD, Diabetic Kidney Disease, eGFR, estimated glomerular filtration rate. eGFR was calculated using CKD-EPI formula The Spearman correlation method with the adjustment of age, sex, and BMI was applied to calculate the associations between the centered log-ratio (clr) transformed counts of each genus and the renal function indicators (UREA, CREA, eGFR) among the overall participants, healthy control, or patients with diabetic kidney disease, *P <0.05. The detailed description of these genera was shown in Supplementary Table 1 and the corresponding statistical results using Spearman were shown in Supplementary Table 4 .