TABLE 2.

Signal detection results of additive and multiplicative models.

Drug A	Drug B	Adverse reaction	Additive model			Multiplicative model
			RDAB	RDA + RDB	Difference	RRAB	RRA*RRB	Ratio
sacubitril/valsartan	atorvastatin	muscle spasms	0.0013	0.0077	−0.0064	1.1467	1.2533	0.9149
		myalgia	−0.0001	0.0188	−0.0189	0.9892	1.9685	0.5025
		muscular weakness	0.0039	0.0089	−0.0049	1.7888	2.4365	0.7342
		musculoskeletal pain	0.0010	0.0029	−0.0018	1.3669	1.4932	0.9154
		rhabdomyolysis	0.0048	0.0044	0.0004	4.0493	2.4402	1.6594
		myopathy	0.0106	0.0055	0.0051	1.5697	0.9803	1.6012
		myositis	0.0009	0.0005	0.0005	3.7380	0.6784	5.5099
		blood creatine phosphokinase increased	0.0052	0.0048	0.0004	5.5515	7.2131	0.7696
		musculoskeletal discomfort	0.0039	0.0023	0.0016	1.7691	1.1394	1.5527
	rosuvastatin	muscle spasms	0.0000	0.0085	−0.0084	1.0034	1.2974	0.7734
		myalgia	0.0050	0.0234	−0.0185	1.6487	2.2695	0.7265
		muscular weakness	0.0103	0.0079	0.0024	3.0665	2.2786	1.3458
		musculoskeletal pain	−0.0015	0.0037	−0.0052	0.4556	1.6857	0.2703
		rhabdomyolysis	0.0060	0.0123	−0.0062	4.8591	5.3326	0.9112
		myopathy	−0.0059	0.0132	−0.0191	0.6825	1.2154	0.5615
		myositis	0.0009	0.0007	0.0002	3.7380	0.8432	4.4330
		blood creatine phosphokinase increased	0.0001	0.0000	0.0001	1.1103	0.7391	1.5023
		musculoskeletal discomfort	−0.0012	0.0099	−0.0111	0.7582	2.0781	0.3649
	simvastatin	muscle spasms	−0.0018	0.0039	−0.0057	0.7936	1.0185	0.7791
		myalgia	−0.0018	0.0152	−0.0171	0.7607	1.7368	0.4380
		muscular weakness	0.0021	0.0067	−0.0046	1.4148	2.0794	0.6804
		musculoskeletal pain	0.0124	0.0019	0.0105	5.4653	1.2804	4.2686
		rhabdomyolysis	0.0043	0.0104	−0.0061	3.7363	4.6295	0.8071
		myopathy	0.0083	−0.0006	0.0089	1.4484	0.7955	1.8207
		myositis	0.0008	0.0006	0.0003	3.4492	0.7365	4.6833
		blood creatine phosphokinase increased	0.0012	−0.0001	0.0013	2.0490	0.5328	3.8457
		musculoskeletal discomfort	−0.0003	0.0039	−0.0042	0.9328	1.3377	0.6973