TABLE 3.

Statistical tests of additive and multiplicative models.

Drug A	Drug B	Adverse reaction	Additive model (α = 0.05)		Multiplicative model (α = 0.05)
			δ	P	exp(δ)	P
sacubitril/valsartan	atorvastatin	rhabdomyolysis	0.0004	0.8903	1.7047	0.2533
		myopathy	0.0054	0.3700	1.6449	0.0193
		myositis	0.0005	0.7163	5.6604	0.1153
		blood creatine phosphokinase increased	0.0005	0.8657	0.7906	0.6087
		musculoskeletal discomfort	0.0016	0.6245	1.5950	0.2263
	rosuvastatin	muscular weakness	−0.001	0.7623	1.0625	0.8381
		myositis	−0.0001	0.9282	3.4998	0.2548
		blood creatine phosphokinase increased	−0.0002	0.8674	1.1860	0.8667
	simvastatin	musculoskeletal pain	0.0106	0.0118	4.3445	< 0.0001
		myopathy	0.0092	0.0995	1.8660	0.0034
		myositis	0.0003	0.8259	4.0056	0.2005
		blood creatine phosphokinase increased	0.0013	0.4218	3.9149	0.0616