Figure 5.

Schematic illustration of circCAMSAP1 promoting proliferation and metastasis of NPC through a positive SERPINH1/c-Myc feedback. circCAMSAP1 bound to and stabilized the 3’ untranslated region of the molecular chaperone SERPINH1 mRNA and promoted SERPINH1 expression.Additionally,the upregulated SERPINH1 protein bound to c-Myc, blocking the latter’s ubiquitination degradation. Furthermore, c-Myc stimulated SRSF10 expression and CAMSAP1 transcription, yielding pre-mRNA, whereas high SRSF10 expression stimulated pre-mRNA splicing, resulting in circCAMSAP1.Moreover C-Myc and SRSF10 jointly promoted circCAMSAP1 formation, resulting in the establishment of a positive feedback loop, leading to NPC proliferation and metastasis.