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Representative confocal and H&E stained images of NaV1.8-tdTomato and PGP9.5-stained WT knees showing neuronal signal within osteophytes (white and black insets respectively) at (A–C) 4,8 and 16 weeks after DMM; (D,E) 4 and 12 weeks after PMX; (F,G) 1 and 4 weeks after ACLR; (H,I) 26-week old and 2-year old naïve mice. White arrows indicate NaV1.8+ signal within the bone marrow of the osteophytes. Scale bar = 100 μm.
