FIG. 7.

p53-independent induction of mdm-2, p21, and gadd45 following d106 infection of H1299 cells. The p53 −/− cell line H1299 was mock infected (lanes M) or infected with d106 or d109 as indicated. At the indicated times (hours postinfection [hpi]), cell lysates were prepared and equal amounts of total protein were separated by SDS-PAGE. Western blot analysis was then performed as described in Materials and Methods for mdm-2, p21, gadd45, and ICP0.