Table 1.
Major clinical research topics in 2012 and 2021
| Topic label | 2012 (Number of documents) | 2021 (Number of documents) |
|---|---|---|
| Risk score and stratification of heart failure | 64 | 303 |
| Treatment of the cardiorenal syndrome | 304 | 356 |
| Heart failure and respiratory sleep disorders | 112 | 80 |
| Methodology of clinical trials | 224 | 432 |
| Amyloidosis and heart failure | 48 | 210 |
| Medications for heart failure | 16 | 146 |
| Heart failure and serum proteins | 288 | 519 |
| Intensive care treatment of heart failure | 160 | 483 |
| Care and readmission of patients with heart failure | 112 | 307 |
| Heart failure and thyroid function | 80 | 113 |
| Psychosocial care for patients with heart failure | 32 | 112 |
| Extracorporeal membrane oxygenation therapy | 272 | 371 |
| Vasoactive drugs and the treatment of heart failure | 16 | 103 |
| Heart failure due to cardiomyopathy—mechanism, diagnosis, and treatment | 400 | 640 |
| Heart failure due to congenital heart disease | 48 | 239 |
| Care and patient education in heart failure | 16 | 110 |
| Acute coronary syndrome and myocardial injury | 160 | 170 |
| Heart failure after myocardial infarction—treatment and prognosis | 224 | 407 |
| Proteins and enzymes | 32 | 135 |
| Dilated cardiomyopathy—etiology, diagnosis, and treatment | 80 | 160 |
| Hypertension—diagnosis, monitoring, and treatment | 96 | 201 |
| Risk factors and predictive models for heart failure | 80 | 146 |
| Imaging—ultrasound, and MRI | 32 | 249 |
| Coagulation, anticoagulation, and atrial fibrillation | 80 | 173 |
| Heart failure and liver dysfunction | 48 | 88 |
| Treatment of acute heart failure—characteristics, influential factors, and prognosis | 64 | 49 |
| Coronary artery lesions and heart failure | 96 | 185 |
| Related care, palliative care, and quality of life in patients with heart failure | 112 | 281 |
| Pulmonary hypertension and heart failure | 208 | 185 |
| Management and rehabilitation of heart failure disease | 16 | 89 |
| Treatment of heart failure—diuretics | 48 | 59 |
| The role of exercise in the diagnosis and rehabilitation of heart failure | 48 | 113 |
| Heart failure and complications in infants and children | 32 | 59 |
| Pacing therapy for arrhythmias | 64 | 65 |
| Basic science and population research | ||
| Cell regeneration and signaling pathways | 144 | 154 |
| Oxygen metabolism and heart failure | 89 | 115 |
| The role of enzymes in the progression of heart failure | 16 | 131 |
| Stem cells, genetics, and gene editing | 48 | 141 |
| Genetics and single nucleotide polymorphisms | 16 | 61 |
| Immune cells and immune regulation | 48 | 72 |
| Health economics of the treatment and care of heart failure | 2012 | 80 |
| Health economics of the treatment and care of heart failure | 2021 | 119 |
| Regional distribution and use of health care related to heart failure | 2012 | 64 |
| Regional distribution and use of health care related to heart failure | 2021 | 139 |