Table 2.

Studies focusing on APOE genotype-defined iPSC lines.

Abnormal factor	NPCs	Neurons	Astrocytes	Microglia	Organoid/multicell	Total studies per factor	Total cell lines per factor
Lipid metabolism		TCW 202234 [4]	Lee 202162 [1] Lin 201863 [2] TCW 202234 [4] de Leeuw 202264 [3]	TCW 202234 [4]		4	10
Energy metabolism
Oxidative stress response
Glutamatergic stress response
Calcium flux
Endo-/Phagocytosis Auto-/Mitophagy		Lin 201863 [2]	Lin 201863 [2] Narayan 202065 [2] de Leeuw 202264 [3]	Lin 201863 [2] Moser 202324 [10]		4	17
Inflammatory pathway activity		TCW 202234 [4]	Lin 201863 [2] Arnaud 202217 [1] de Leeuw 202264 [3]	Lin 201863 [2] TCW 202234 [4] Moser 202324 [10]		4	20
Total studies		2	6	3
Total LOAD cell lines		6	14	16

Included are studies that use isogenic APOE lines generated from healthy individuals or from patients with LOAD, as well as results from studies using iPSC lines derived from APOE haplotype carriers. In some studies, a combination of such APOE-specified lines was used. Organization and meaning of the items in the table is the same as in Table 1.