Table 2.

Proposed motor and non-motor subtypes of Parkinson’s disease.

Subtype Proposed	Number of Subtypes	Basis of Classification	References
• Mild motor dominant      • Diffuse motor dominant      • Malignant motor dominant	3	Predominantly motor	[35]
• Tremor-dominant      • Indeterminate      • Postural instability and gait	3	Predominantly motor	[144, 145]
• Tremor-dominant      • Mixed      • Akinetic-rigid	3	Predominantly motor	[146-148]
• Tremor-dominant      • Akinetic-rigid      • Gait difficulties      • Mixed	4	Predominantly motor	[149]
• Fast motor      • Mild motor and non-motor      • Severe motor      • Slow motor	4	Mixed motor and non-motor	[150]
• Mild motor and non-motor symptoms      • Severe non-motor, but mild motor symptoms      • Severe motor, but mild non-motor symptoms      • Severe motor and non-motor symptoms	4	Mixed motor and non-motor	[34]
• Impulse control problems      • Overall non-motor symptoms      • Dyskinesias and psychosis      • Fatigue      • Axial symptoms and motor fluctuations      • Autonomic dysfunction      • Depression      • Excessive sweating	8	Mixed motor and non-motor	[116]
• Brainstem      • Limbic      • Cortical	3	Predominantly non-motor	[36]
• Cognition      • Apathy      • Depression/Anxiety      • Sleep      • Pain      • Fatigue      • Autonomic	7	Predominantly non-motor	[25, 51]
• Cholinergic      • Serotonergic      • Noradrenergic      • Mixed	4	Predominantly non-motor	[25, 51]
• Mild baseline moderate progression      • Moderate baseline mild progression      • Severe baseline rapid progression	3	Mixed motor and non-motor	[118]