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Mechanism of action of armodafinil: Prefrontal cortex, increase the concentration of dopamine (DA) through inhibition of dopamine transporter (DAT) and can promote GABAergic, glutamatergic and serotonergic activity. Nucleus accumbens, increase the concentration DA through inhibition of DAT. Striatum, increased serotonin metabolism. Hypothalamus, promotes glutamatergic synapse in hypocretin/orexin neurons and is capable of inhibiting activity of the preoptic nucleus.
