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. 2024 Jul 11;67(14):11841–11867. doi: 10.1021/acs.jmedchem.4c00465

Table 2. Binding Affinities and Functional Activity of the N-Boc-Protected DEG Probe Precursors.

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a

Ki (nM) values obtained from [3H]CP55,940 displacement assays on CHO cell membranes stably expressing human CB1R or human CB2R. Values are means of three independent experiments performed in duplicate.

b

The activity levels (IC50) of 22b and 23b were measured using cells stably expressing hCB1R in homogeneous time-resolved fluorescence (HTRF) cAMP assay. The data are the means of three independent experiments performed in technical replicates.

c

Maximum effect (Emax in %) was normalized to reference full agonist CP55,940. n.d. is not determined. All data with standard error of mean are given in the Supporting Information.