Table 6.

Synthesis of the results on feasibility, measurement properties, and relevance of the PROMIS measures for adults with von Willebrand disease.

		Feasibility		Construct validitya	Reliability	Relevanceb
PROMIS measure	SF-36v2	Number of items	Floor/ceiling effects
CATs
Physical function	Physical functioning	+	+	++	++	+
Pain interference	Bodily pain	-	±	++	++	-
Fatigue	Vitality	-	±	++	++
Anxiety	Mental health	-	±	+	++	-
Depression	Mental health	-	-	+	++	-
Ability to participate in social roles and activities	Social functioning	-	+	++	++	-
Satisfaction with social roles and activities	Social functioning	-	+		++	-
PROMIS short form
Anger					++
Fixed scale
Global health – physical health	Physical functioning	+	+		+
	Physical component summary	+	±
Global health – mental health	Mental health	+	-		+
	Mental component summary	+	-

Interpretation: Number of items: + on average the mean number of CAT items shown was lower than the number of items on the SF-36v2, - on average the mean number of CAT items shown was higher than the number of items on the SF-36v2. Floor/ceiling: + no or less floor- and/or ceiling effects then the SF-36v2, ± similar floor- and/ or ceiling effects than the SF-36v2, - more floor- and/or ceiling effects then the SF-36v2. Relevance: + patients reported more symptoms than the general population, – patients reported fewer or similar symptoms than the general population. Construct validity: ++ all construct validity criteria are met, + not all construct validity criteria are met but >70% of the correlations between DPSP and DPDP are smaller than the correlation between SPDP, - construct validity criteria are not met and <70% of the correlations between DPSP and DPDP are smaller than the correlation between SPDP Reliability: ++ reliability coefficient or greatest lower bound ≥ 0.90, + reliability coefficient or greatest lower bound ≥ 0.70, - reliability coefficient or greatest lower bound ≤0.70.

CAT, computer adaptive test; DPDP, different patient-reported outcome different patient-reported outcome measure; DPSP, different patient-reported outcome same patient-reported outcome measure; PROMIS, patient-reported outcomes measurement information system; SF-36v2, Short Form-36 version 2; SPDP, same patient-reported outcome different patient-reported outcome measure.

^aConstruct validity was only determined for the PROMIS CATs physical function, pain interference, fatigue, anxiety, depression, and ability to participate in social roles and activities.

^bRelevance, as in comparison with the general Dutch population, was only determined for the PROMIS CATs physical function, pain interference, anxiety, depression. ability to participate in social roles and activities, and satisfaction with social roles and activities.