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. 1996 Jun;53(6):399–402. doi: 10.1136/oem.53.6.399

Lung cancer in asbestos cement workers in Denmark.

E Raffn 1, E Villadsen 1, G Engholm 1, E Lynge 1
PMCID: PMC1128496  PMID: 8758035

Abstract

OBJECTIVES: To study the relative and absolute risks of main types of lung cancer in a cohort of asbestos cement workers from Denmark. METHOD: A cohort of 7887 men and 576 women employed between 1928 and 1984 was compiled from the personnel files of Danish Eternit Production. The cohort was followed up for deaths, emigrations, and incident cancer cases during the period 1943-90. The observed number of lung cancer cases in the cohort was compared with the expected number based on incidences for the Danish population. Internal comparison was made with Poisson modelling. RESULTS: A total of 226 lung cancer cases were observed (223 men and three women). The standardised incidence ratio (SIR) for all lung cancer among men was 1.7 (observed number 223, expected number 129.7, 95% confidence interval (95% CI) 1.5-2.0). The SIRs were raised for all main types of lung cancer; adenocarcinoma 2.6, squamous cell carcinoma 1.7, and anaplastic carcinoma 1.5. The higher SIR for adenocarcinomas was found particularly with a latency period of 25 years or more. Among the 93 excess lung cancer cases, 36 were squamous cell carcinomas and 32 were adenocarcinomas. CONCLUSION: Asbestos cement work is associated with an increased risk of lung cancer of all main types. During the first 25 years after the start of employment this excess risk is shared almost equally between the different histological types of lung cancer, but the risk of adenocarcinomas is clearly higher after this point.

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Selected References

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  1. Bovenzi M., Stanta G., Antiga G., Peruzzo P., Cavallieri F. Occupational exposure and lung cancer risk in a coastal area of northeastern Italy. Int Arch Occup Environ Health. 1993;65(1):35–41. doi: 10.1007/BF00586056. [DOI] [PubMed] [Google Scholar]
  2. CLEMMESEN J. STATISTICAL STUDIES IN THE AETIOLOGY OF MALIGNANT NEOPLASMS. I. REVIEW AND RESULTS. SUPPLEMENT 174. I. Acta Pathol Microbiol Scand Suppl. 1965;174:1–543. [PubMed] [Google Scholar]
  3. Clemmesen J., Hjalgrim-Jensen S. Cancer incidence among 5686 asbestos-cement workers followed from 1943 through 1976. Ecotoxicol Environ Saf. 1981 Mar;5(1):15–23. doi: 10.1016/0147-6513(81)90042-7. [DOI] [PubMed] [Google Scholar]
  4. Clemmesen J. Statistical studies in the aetiology of malignant neoplasms. V. Trends and risks. Denmark 1943--72. Acta Pathol Microbiol Scand Suppl. 1977;(261):1–286. [PubMed] [Google Scholar]
  5. Johansson L., Albin M., Jakobsson K., Mikoczy Z. Histological type of lung carcinoma in asbestos cement workers and matched controls. Br J Ind Med. 1992 Sep;49(9):626–630. doi: 10.1136/oem.49.9.626. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Karjalainen A., Anttila S., Vanhala E., Vainio H. Asbestos exposure and the risk of lung cancer in a general urban population. Scand J Work Environ Health. 1994 Aug;20(4):243–250. doi: 10.5271/sjweh.1401. [DOI] [PubMed] [Google Scholar]
  7. Kjuus H., Skjaerven R., Langård S., Lien J. T., Aamodt T. A case-referent study of lung cancer, occupational exposures and smoking. II. Role of asbestos exposure. Scand J Work Environ Health. 1986 Jun;12(3):203–209. doi: 10.5271/sjweh.2157. [DOI] [PubMed] [Google Scholar]
  8. Minowa M., Hatano S., Ashizawa M., Oguro H., Naruhashi H., Suzuki M., Mitoku K., Miwa M., Wakamatsu C., Yasuda Y. A case-control study of lung cancer with special reference to asbestos exposure. Environ Health Perspect. 1991 Aug;94:39–42. doi: 10.1289/ehp.94-1567972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Nielsen P. E., Krarup N. B., Astrup J., Gyntelberg F., Lisse O. Aendring i danskernes rygevaner 1958-1976. Ugeskr Laeger. 1978 Oct 9;140(41):2528–2532. [PubMed] [Google Scholar]
  10. Raffn E., Lynge E., Juel K., Korsgaard B. Incidence of cancer and mortality among employees in the asbestos cement industry in Denmark. Br J Ind Med. 1989 Feb;46(2):90–96. doi: 10.1136/oem.46.2.90. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Raffn E., Lynge E., Korsgaard B. Incidence of lung cancer by histological type among asbestos cement workers in Denmark. Br J Ind Med. 1993 Jan;50(1):85–89. doi: 10.1136/oem.50.1.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Vainio H., Boffetta P. Mechanisms of the combined effect of asbestos and smoking in the etiology of lung cancer. Scand J Work Environ Health. 1994 Aug;20(4):235–242. doi: 10.5271/sjweh.1402. [DOI] [PubMed] [Google Scholar]

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