Table 3.
Differences in mean changes in fasting and 2-hour blood glucose between participants with normal blood glucose and those with pre-diabetes mellitus over 48 weeks
| Characteristic | Pre-diabetes | Normal blood glucose | Difference | P-value | *Adjusted difference in mean changes | P-value |
|---|---|---|---|---|---|---|
| Mean change (95% CI) | Mean change (95% CI) | Mean change (95% CI) | ||||
| Fasting blood glucose | ||||||
| Baseline to week 12 | -7.43 (-10.33, -4.54) | 1.25 (-0.74, 3.25) | -8.69 (-12.14, -5.24) | < 0.0001 | -8.69 (-12.24, -5.15) | < 0.0001 |
| Baseline to week 24 | -5.40 (-8.88, -1.92) | 2.74 (1.13, 4.35) | -8.14 (-11.45, -4.83) | < 0.0001 | -8.20 (-11.61, -4.79) | < 0.0001 |
| Baseline to week 36 | -7.32 (-9.90, -4.75) | 4.23 (2.62, 5.85) | -11.56 (-14.45, -8.67) | < 0.0001 | -11.36 (-14.27, -8.44) | < 0.0001 |
| Baseline to week 48 | -6.12 (-9.08, -3.16) | 3.95 (2.16, 5.73) | -10.07 (-13.32, -6.82) | < 0.0001 | -10.03 (-13.25, -6.82) | < 0.0001 |
| 2-hour OGTT glucose | ||||||
| Baseline to week 12 | -28.53 (-38.97, -18.10) | -8.86 (-14.12, -3.61) | -19.67 (-30.01, -9.33) | 0.0003 | -19.69 (-30.19, -9.19) | < 0.0001 |
| Baseline to week 36 | -23.03 (-33.44, -12.63) | -3.38 (-8.56, 1.81) | -19.65 (-29.91 (-9.30) | 0.0002 | -19.97 (-30.56, -9.39) | < 0.0001 |
CI- confidence interval, OGTT- Oral glucose tolerance test. * Adjusted for baseline age, BMI, CD4 + cell count, sex and 24-week viral load