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. 2024 Jul 27;19(1):2380930. doi: 10.1080/15592294.2024.2380930

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© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 6. — Transgenerational DMRs in untreated generations overlap at both DMR location and gene-level, suggesting commonality of molecular changes caused by ancestral FA treatment. (a) A Venn diagram depicts the overlap of DMRs, based on genomic coordinates, from the F1 (red), F2 (blue), and F3 (yellow) generations. (b) A heatmap shows the unsupervised hierarchical clustering of tested samples using the mean DNA methylation levels from the 10 transgenerational DMRs that are identified in all 3 generations. (c) An UpSet plot shows the overlap of transgenerational DMR-associated genes between the generations that were not directly treated (i.e., F1–F3). Green bars show the number of DMR-associated genes for each generation. Purple bars show the number of DMR-associated genes specific to each tested overlap.