Andersen 2010.
Methods | Randomised controlled trial of fertility patients in Denmark | |
Participants | Patients (n = 635) scheduled for embryo transfer were randomised into acupuncture according to the principles of Traditional Chinese Medicine (n = 314) or placebo acupuncture (n = 321). The average age of the two groups of women was 31 years and the average body mass index (BMI) was 22.5 for both groups. There were similar numbers of previous IVF/ICSI cycles and similar proportions of causes of infertility between both groups. |
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Interventions | Needle acupuncture or placebo acupuncture using Strietberger placebo needle for 25 minutes before and after embryo transfer; performed by nurses who were professional acupuncturists or by nurses who had received instruction and training by the acupuncturists prior to the trial | |
Outcomes | Ongoing pregnancy rate, implantation and pregnancy rates, live birth rates | |
Assisted conception protocols | Standard, long protocol GnRH down‐regulation and the follicle stimulating hormone (FSH) or human menopausal gonadotrophin (hMG) | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Random sequence generation – LOW RISK ‐ ‘the sequence of cluster randomization was based on a computer‐generated list’ |
Allocation concealment (selection bias) | Unclear risk | ‘nurses did the randomization with the sealed envelope technique’ |
Blinding (performance bias and detection bias) All outcomes | Low risk | Sequence allocation was performed by nurses and the procedure was performed blinded to patients and the clinician performing ET |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No patients lost to follow up |
Selective reporting (reporting bias) | Low risk | None known |
Other bias | Low risk | None known |