Moy 2011.
Methods | Randomized controlled trial of fertility patients in US | |
Participants | 160 patients undergoing IVF ± ICSI were randomised to either true acupuncture (n = 87) or sham acupuncture (n = 74) The average age (± SD) in the true acupuncture group was 33.3 (± 0.307) years compared to 33.16 (± 0.334) years in the sham acupuncture group. There was no statistically significant difference in BMI or infertility diagnosis between the two groups, with the leading causes of infertility being male factor, ovarian dysfunction and unexplained. |
|
Interventions | True (needle) acupuncture performed by hospital employed licensed acupuncturists versus sham placebo acupuncture. Both interventions performed for 25 minutes before and after embryo transfer | |
Outcomes | Clinical pregnancy rate and clinical symptoms during embryo transfer | |
Assisted conception protocols | Protocol breakdown not provided | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | patients were randomized using a ‘random number generator’ |
Allocation concealment (selection bias) | Low risk | Use of 'sealed, sequentially numbered, opaque envelopes’. |
Blinding (performance bias and detection bias) All outcomes | Low risk | Control group was allocated to Sham acupuncture. The physicians and patients were blinded to the randomization until the conclusion of the study. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | 160 participants were randomized; 1 lost to follow up |
Selective reporting (reporting bias) | Unclear risk | LBR outcome data not reported. |
Other bias | Low risk | None |