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. 2022 Nov 1;2:1054069. doi: 10.3389/fmmed.2022.1054069

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Copyright © 2022 Suoranta, Laham-Karam and Ylä-Herttuala.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of wild-type AAV2, its encapsulated genome and the known open reading frames. ITR: inverted terminal repeat. RBE: Rep binding element, trs: terminal resolution site D: D-sequence, P5, P19, P40, and P81: viral promoters, Rep78, Rep68, Rep52, and Rep40: proteins coded by rep, involved in genome replication and packaging. VP1, VP2, and VP3: structural capsid proteins coded by cap, MAAP: membrane associated accessory protein, AAP: assembly activating protein, X: protein X, polyA: viral polyadenylation signal.