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. 2022 Nov 1;2:1054069. doi: 10.3389/fmmed.2022.1054069

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Copyright © 2022 Suoranta, Laham-Karam and Ylä-Herttuala.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CpG motifs (in black) and the optimal mouse TLR9 recognition motif (highlighted) found in the AAV2 ITR sequence. ITR: inverted terminal repeat. Flop: hairpin sequence orientation, C, C′, B and B′: hairpin elements, RBE: Rep binding element, trs: terminal resolution site. Figure generated with SnapGene.