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. 2022 Sep 20;2:1011882. doi: 10.3389/fmmed.2022.1011882

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Copyright © 2022 F., V. D., C., M., C., G., D., A., M., S., M., V. and G..

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epigenetic alterations responsible for the initiation and maintenance of cancer stem cells (CSCs). An aberrant epigenetic reprogramming plays a critical role in CSC initiation and maintenance, driving the transformation process of a normal stem cell (NSC) versus a cancer stem cell (CSC). The principal alterations involving the epigenetic regulators that sustain the formation (left) and the maintenance (right) of this aggressive subpopulation are indicated along with the functions/properties of CSCs that these enzymes are promoting.