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. 2022 Sep 20;2:1011882. doi: 10.3389/fmmed.2022.1011882

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Copyright © 2022 F., V. D., C., M., C., G., D., A., M., S., M., V. and G..

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epigenetic therapy using NSCs in regenerative medicine and targeting CSCs in tumors (left) Epigenetically engineered adult normal stem cells (NSCs) or induced pluripotent stem cells (iPSCs) represent an innovative and promising tool in regenerative medicine. Adult stem cells deriving from damaged tissue or iPSCs could be reprogrammed using the indicated epigenetic drugs in order to obtain a specific lineage commitment, thus allowing tissue repair and regeneration. (right) On the other hand, the use of epigenetic inhibitors in cancer therapy targeting the aberrant epigenetic modifications responsible for CSC initiation and maintenance may lead to a reduction of tumor mass by inhibiting the stemness features of CSC subpopulation.