TABLE 3.
Linear regression analysis included multivariable models fitted with the most significant predictors of flow-mediated dilation.
| Model R2 (%) | b-coefficient | 95% CI | p-value | |
|---|---|---|---|---|
| Model 1 | ||||
| Age (years) | 5.4 | −0.073 | −0.238 to −0.064 | 0.449 |
| Pulse pressure (mmHg) | −0.011 | −0.321 to 0.038 | 0.924 | |
| Smoking | 0.081 | 0.056 to 0.278 | 0.401 | |
| LDL-C (mg/dl) | −0.001 | −0.412 to 0.089 | 0.993 | |
| Insulin (μIU/ml) | −0.172 | −0.368 to −0.063 | 0.085 | |
| BMI (kg/m2) | −0.026 | −0.378 to 0.032 | 0.789 | |
| HSP60 | 0.171 | 0.043 to 0.358 | 0.046 | |
| Model 2 | ||||
| Age (years) | 2.5 | −0.062 | −0.268 to 0.037 | 0.438 |
| Pulse pressure (mmHg) | −0.047 | −0.142 to 0.094 | 0.551 | |
| Smoking | −0.029 | −0.142 to 0.328 | 0.715 | |
| LDL-C (mg/dl) | −0.040 | −0.418 to 0.275 | 0.611 | |
| Insulin (μIU/ml) | −0.146 | −0.357 to −0.006 | 0.064 | |
| BMI (kg/m2) | 0.005 | −0.042 to 0.184 | 0.953 | |
| HSP60 | 0.128 | −0.052 to 0.421 | 0.105 | |
| Testosterone (ng/dl) | −0.158 | −0.305 to 0.099 | 0.047 | |
| Model 3 | ||||
| Age (years) | 3.3 | −0.052 | −0.326 to 0.048 | 0.535 |
| Pulse pressure (mmHg) | −0.029 | −0.328 to 0.121 | 0.731 | |
| Smoking | 0.019 | −0.094 to 0.211 | 0.817 | |
| LDL-C (mg/dl) | −0.036 | −0.279 to 0.189 | 0.668 | |
| Insulin (μIU/ml) | −0.132 | −0.367 to 0.083 | 0.113 | |
| BMI (kg/m2) | −0.014 | −0.184 to 0.327 | 0.869 | |
| HSP60 | 0.181 | 0.048 to 0.466 | 0.030 | |
| DHEAS (ng/dl) | −0.160 | −0.354 to −0.045 | 0.053 | |
| Model 4 | ||||
| Age (years) | 8.0 | −0.049 | −0.258 to 0.009 | 0.535 |
| Pulse pressure (mmHg) | −0.029 | −0.198 to 0.205 | 0.711 | |
| Smoking | −0.025 | −0.274 to 0.178 | 0.753 | |
| LDL-C (mg/dl) | 0.008 | −0.047 to 0.149 | 0.921 | |
| Insulin (μIU/ml) | −0.166 | −0.322 to −0.093 | 0.034 | |
| BMI (kg/m2) | 0.096 | 0.003 to 0.389 | 0.271 | |
| HSP60 | 0.141 | −0.093 to 0.338 | 0.066 | |
| Testosterone | −0.165 | −0.395 to 0.038 | 0.034 | |
| DHEAS (ng/dl) | −0.187 | −0.362 to −0.093 | 0.017 | |
*Adjustment for values of follicle-stimulating hormone did not substantially change the results of the above models. Bold indicates statistical significance, which was defined as p-value < 0.05.
SBP, systolic blood pressure; LDL-C, low density lipoprotein cholesterol; BMI, body mass index; HSP60, heat shock protein 60; DHEAS, dehydroepiandrosterone; Model 2, Model 1 + testosterone; Model 3, Model 1 + DHEAS; Model 4, Model 3 + DHEAS.