Table 2. Resistance to serum killing among E. coli bloodstream infection isolates, stratified by multilocus sequence type (ST).
A serum bactericidal assay was performed on each E. coli isolate, and survival was determined by number of colonies in the serum-treated sample (either 25% or 50% serum) divided by the number of colonies in the negative serum control. The mean survival and range of survival values for each E. coli ST with ≥5 isolates in our study population are shown here. P-values were calculated with t-tests (e.g., proportion of surviving bacteria in ST12 relative to non-ST12 isolates). P-values ≤0.05 are in bold.
25% serum | 50% serum | ||||||
---|---|---|---|---|---|---|---|
ST | # isolates | Mean proportion surviving | Range of proportion surviving | P-value | Mean proportion surviving | Range of proportion surviving | P-value |
12 | 7 | 0.72 | 0.65–0.90 | 0.21 | 0.71 | 0.66–0.89 | 0.20 |
69 | 12 | 0.70 | 0.65–0.93 | 0.41 | 0.69 | 0.61–0.94 | 0.41 |
73 | 12 | 0.68 | 0.61–0.77 | 0.97 | 0.67 | 0.58–0.72 | 0.88 |
95 | 18 | 0.68 | 0.62–0.92 | 0.84 | 0.68 | 0.59–0.93 | 0.60 |
127 | 5 | 0.68 | 0.66–0.70 | 1.00 | 0.67 | 0.64–0.71 | 1.00 |
131 | 67 | 0.67 | 0.61–0.74 | 0.05 | 0.66 | 0.60–0.73 | 0.05 |
393 | 10 | 0.66 | 0.57–0.76 | 0.17 | 0.66 | 0.60–0.74 | 0.41 |
405 | 6 | 0.67 | 0.64–0.70 | 0.29 | 0.66 | 0.62–0.68 | 0.50 |