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. 2024 Jul 29;19(7):e0307922. doi: 10.1371/journal.pone.0307922

Fig 4. Immunoblotting for insulin sensitivity markers.

Fig 4

There was a significant increase in RBP-4 from the control non-ischemic group (CON-N) to the control ischemic group (CON-I). RBP-4 was increased in the sitagliptin non-ischemic group (SIT-N) compared to CON-N. There was a significant decrease in RBP-4 in the sitagliptin ischemic (SIT-I) myocardium compared to CON-I to levels similar to the CON-N myocardium. PI3K was significantly increased in CON-I compared to CON-N. There was a significant decrease in PI3K in SIT-I compared to CON-I similar to CON-N. SIRT1 was significantly decreased in CON-I and SIT-N compared to CON-N. pPKC alpha was significantly decreased in SIT-I compared to CON-I. There was also a significant decrease in pPKC alpha in the SIT-I myocardium compared to SIT-N. Data points are mean fold change after normalization to average control. *<0.05, **p<0.01,***p<0.001.