Table 2. Amino acids defining lineages in human respiratory syncytial virus B*.
| Lineage | NS1 | NS2 | N | P | M | SH | G | F | M2–1 | M2–2 | L |
|---|---|---|---|---|---|---|---|---|---|---|---|
| B.1 | 103(K)I; 133(T)P; 222(K)D | 114(Y)H | 148(E)D; 948(N)H; 1177(I)M; 1613(K)N; 2014(A)S | ||||||||
| B.2 | 124(D)N | 24(E)D | 66(I)T | 95(S)P†; 118(I)T; 137(I)T; 150(S)P; 206(I)T; 220(M)T; 221(P)T; 275(S)L†; 283(Y)S; 289(S)P; 298(I)T; 311(X)Q†; 314(X)Q | 103(V)A†; 209(K)Q; 312(H)P | 41(Y)H; 49(C)R†; 68(T)A | 308(I)V; 1742(T)M; 2021(N)D | ||||
| B.3 | 4(H)N; 77(Q)S; 101(S)P; 137(I)T; 140(S)P; 150(S)P; 152(S)P; 154(N)I; 206(I)T; 221(P)L; 283(Y)S; 298(I)T; 311(X)Q | 103(V)A†; 209(K)Q; 312(H)P; 518(T)A†; 529(T)A | 184(T)N; 308(I)V; 1043(I)V; 1547(K)R; 1700(N)D; 1764(K)R; 2021(N)D; 2042(T)I | ||||||||
| B.4 | 45(A)T; 105(M)I† | 89(I)T | 57(L)Q | 4(H)N; 32(R)K; 101(S)P; 109(S)P; 137(I)T; 140(S)P; 143(T)N; 150(S)P; 152(S)P; 205(T)P; 206(I)T; 217(P)L; 221(P)L; 235(L)P; 283(Y)S; 298(I)T; 311(X)Q | 103(V)A; 209(K)Q; 312(H)P; 529(T)A | 184(T)N; 308(I)V; 1043(I)V; 1250(G)S; 1700(N)D; 1726(S)R; 1764(K)R; 2021(N)D; 2042(T)I; 2065(K)N | |||||
| B.D | 138(N)H | 372(A)T† | 138(T)S†; 157delKK†; 221(L)P†; 227(T)I†; 239dupERDTSTSQSTVLDTTTSKHT; 285(H)Y†; 311(X)Q†; 314(X)Q† | 45(F)L† | 142(N)S† | 177(H)Y; 1716(M)I†; 1787(A)E† | |||||
| B.D.1 | 82(T)S | 89(T)I | 290(E)G†; 311(Q)X† | 1593(N)S | |||||||
| B.D.1.1 | 63(I)V | 75(T)S; 204(P)T; 217(L)P; 227(I)T | 19(A)T | 59(M)I; 1250(G)S | |||||||
| B.D.2 | 145(I)V | 87(I)T; 178(Q)R†; 239(E)K | 23(T)A | 181(V)I | 1250(G)S; 1588(I)L | ||||||
| B.D.3 | 4(T)K; 80(K)T† | 87(I)T; 217(L)P; 268(I)T; 285(Y)H; 299(P)S; 311(Q)X | 123(K)G; 124(N)S | 188(T)P | 3(K)N; 43(H)Y | 1489(A)V; 1588(I)L | |||||
| B.D.4 | 49(T)I | 198(I)T | 103(A)V; 172(L)Q | 181(V)I | |||||||
| B.D.4.1 | 216(H)Y† | 107(T)A; 136(R)T; 252(T)I†; 279(I)T | 173(S)L | 715(I)V†; 1712(T)A | |||||||
| B.D.4.1.1 | 64(N)D† | 131(A)T†; 137(T)I†; 288(T)I† | 191(K)R; 206(I)M; 209(Q)R | 1479(V)A†; 1716(I)V† | |||||||
| B.D.E.1 | 100(S)G†; 214(P)S; 221(P)L; 252(I)T; 256(K)N†; 268(I)T; 275(S)P; 285(Y)H | 190(S)N; 211(S)N; 389(S)P | 27(M)T†; 35(D)N; 49(C)F | 570(K)R†; 1759(R)K | |||||||
| B.D.E.2 | 303(I)V | 176(N)S; 269(A)V; 274(T)A† | 1707(H)N | ||||||||
| B.D.E.3 | 1(M)V | 104(Q)H; 128(H)Y; 135(G)S; 141(T)K; 299(P)S†; 311(X)Q† | 19(A)V; 526(M)V | 75(H)Y† | 1965(V)A† | ||||||
| B.D.E.4 | 61(N)T | 135(G)S†; 138(S)F†; 300(T)A; 303(E)G | 164(V)M; 309(V)L; 824(I)M†; 1489(A)T/M; 1732(C)Y |
*The lineage-defining amino acids within each viral protein are detailed. This description provides the location of the amino acid using the genome coordinates HRSV/B/AUS/VIC-RCH056/2019 (lineage B.D.4.1.1, National Center for Biotechnology Information Virus (https://www.ncbi.nlm.nih.gov/labs/virus) accession no. OP975389.1, GISAID EpiRSV (https://www.gisaid.org) accession no. EPI_ISL_1653999), followed by the amino acid found in the parental lineage in parentheses. Finally, the amino acid substitution that drives it to become a lineage is specified. X represents an amino acid deletion NS, nonstructural protein; N, nucleocapsid; P, phosphoprotein; M, matrix protein; SH, small hydrophobic protein; G, attachment glycoprotein; F, fusion glycoprotein; M2, M2 protein; L, large polymerase protein. †Amino acid changes detected in not all but >90% of the lineage sequences.