Skip to main content
. Author manuscript; available in PMC: 2024 Jul 29.
Published in final edited form as: Xenotransplantation. 2023 Apr 7;30(3):e12802. doi: 10.1111/xen.12802

Table 1:

Selected experience with mTOR-inhibitors in pig-to-baboon organ transplantation

Year
(Reference)		 Pig organ
(Gene-editing)		 Heterotopic/Life-supporting Maximal graft survival (days)
(Cause of termination of experiment)
2005
(McGregor et al)4 		Heart
(CD46)		 Heterotopic 137
(Rejection)
2005
(Brandl et al)5 		Heart
(CD55)		 Life-supporting 25
(Rejection)
2011
(Byrne et al)6 		Heart
(CD46/TPC)		 Life-supporting 57
(Infection/PTLD)
2015
(Iwase et al)7 		Kidney
(GTKO/CD46/CD55/TBM/EPCR/CD39)		 Life-supporting 136
(Infection)
2017
(Iwase et al)8 		Kidney
(GTKO/CD46/CD55/EPCR/ TFPI/CD47)		 Life-supporting 260
(Infection)
2020
(Reichart et al)9 		Heart
(GTKO/CD46/TBM)		 Life-supporting 195
(Study end-point)

EPCR = endothelial protein C receptor; PTLD = post-transplant lymphoproliferative disease; TBM = thrombomodulin; TFPI = tissue factor pathway inhibitor; TPC; polyethylene glycol α-Gal polymer.