Table 2.
Demographics of populations used for model development in publications chosen for analysis.
| Variable | Median (Range) or N (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Potts15 | James16 | Morse (Five Pooled Datasets)a, 17 | Pérez-Guilléb, 18 | Wiczling19 | |||||
| Postnatal age (years) | 3.83 (0.01–14.4) | 1.3 (0.003–22.6) | 3.83 (0.01–14.4) | 20–70 | 38 (18–60) | 42.3 (23–59) | 29 (21–36) | 11 (5) | 5.83 (0.12–15.7) |
| Weight (kg) | 16.1 (3.1–58.9) | 9.4 (2–138) | 16.1 (3.1–58.9) | 51–110 | 95 (59–152) | 90 (47–126) | 72 (52–89) | 43 (19) | 18.5 (4.7–60) |
| Female | NR (N = 95) | 171 (48%) | NR (N = 95) | NR (N = 18) | 14 (35%) | 26 (65%) | 5 (50%) | 21 (70%) | 15 (39.5%) |
| Infusion Dose (μg/kg/hr) | 0.2 | 0.6 (0.03–2.0) | 0.2 | 6 | 0.25–0.5 | 0.5 | 1 | 2.4–4.2c | 0.8–1.4 |
| Bolus Dose (μg/kg) | 1–6 | 1.0 (0.06–4.21) | 1–6 | NA | NA | NA | NA | NA | NA |
NR: Not reported, NA: Dosing type not included in analysis
a
From left to right, the pooled datasets are from studies by Potts et al.15, Hannivoort et al.7, Cortinez et al.45, Rolle et al.13, and Talke et al.46. Only one study included pediatric data, though the model is described as a ‘Universal Population PK Model’, indicating it is intended for use in children as well as adults.
b
Reported as mean (SD), age range reported to be limited to 2–18 years old
c
Given as 10–15 minute infusions only