Table 2.

RORs and IC for DRESS syndrome by class of antipsychotic and for individual antipsychotics

Drug	n DRESS syndrome cases	n all ADRs	ROR	Lower 95% CI	Upper 95% CI	IC	Lower 95% CI	Upper 95% CI
Antipsychotics	1,356	728,105	1.0	0.9	1.1	0.0	−0.1	0.1
Atypical	1,224	595,520	1.1*	1.0	1.2	0.1*	0.0	0.2
Typical	175	101,520	0.9	0.8	1.0	−0.2	−0.4	0.0
Typical antipsychotics
Haloperidol	57	35,870	0.8	0.6	1.1	−0.3	−0.7	0.0
Chlorpromazine	37	12,636	1.5*	1.1	2.1	0.6*	0.1	1.0
Cyamemazine	23	5188	2.3*	1.5	3.5	1.2*	0.5	1.7
Levomepromazine	13	5368	1.3	0.7	2.4	0.3	−0.6	1.0
Loxapine	11	3775	1.5	0.8	2.8	0.6	−0.4	1.3
Zuclopenthixol	11	4359	1.3	0.7	2.4	0.4	−0.6	1.1
Perphenazine	6	3323	0.9	0.4	2.0	−0.1	−1.5	0.8
Droperidol	5	2197	1.2	0.5	2.9	0.2	−1.3	1.2
Atypical antipsychotics
Clozapine	800	184,094	2.3*	2.1	2.5	1.2*	1.1	1.3
Olanzapine	152	71,859	1.1	0.9	1.3	0.1	−0.1	0.3
Quetiapine	134	87,822	0.8	0.7	0.9	−0.3	−0.6	−0.1
Risperidone	89	114,334	0.4	0.3	0.5	−1.3	−1.6	−1.1
Aripiprazole	61	70,082	0.5	0.4	0.6	−1.1	−1.5	−0.8
Lurasidone	23	13,145	0.9	0.6	1.4	−0.1	−0.8	0.4
Ziprasidone	23	14,911	0.8	0.5	1.3	−0.3	−1.0	0.2
Amisulpride	16	7725	1.1	0.7	1.7	0.1	−0.7	0.7
Paliperidone	12	47,633	0.1	0.1	0.1	−2.9	−3.8	−2.2
Sulpiride	7	4861	0.8	0.4	1.6	−0.4	−1.6	0.5
Tiapride	7	1922	1.9	0.9	4.0	0.8	−0.4	1.7

RORs are considered statistically significant when the lower CI limit is > 1 and ICs are considered statistically significant when the lower CI limit is > 0

ADR adverse drug reaction, CI confidence interval, DRESS drug reaction with eosinophilia and systemic symptoms, IC information component, n number, ROR reporting odds ratio

*Significant