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. 2024 Jul 29;14:17439. doi: 10.1038/s41598-024-67641-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Epigenetic clock analysis of pair bonding status in brain samples. Age of adult sex-naive animals (x-axis) versus the age estimate according to the pan-tissue vole clock trained on pair-bonded animals in (A) all tissues combined, (C) individual tissues (blood, brain, ear, and liver). Age of adult pair-bonded animals (x-axis) versus the age estimate according to the pan-tissue vole clock trained on sex-naive animals (y-axis) in (D) all tissues combined, (F) individual tissues. Dots are colored by tissue type: green = blood, orange = brain, purple = ear, pink = liver. Samples are labelled by sex (F = female, M = male). (B,E) Age adjusted estimates of the cross validated age estimates versus tissue. The error bars depict two standard errors, so if they cross over the 0-line, then the two-sided p-value is greater than 0.05. All voles younger than 0.3 years were sex-naive and were therefore restricted from these analyses. For panels (A), (C), (D), and (F), the black solid and dashed lines correspond to the regression line and the diagonal reference line (y = x), respectively.