Table 6.
Results of univariate and multivariate analyses in prediction of the outcome endpoints
| Univariate | Multivariate model 1 (LR χ 2: 27.15) | Multivariate MODEL 2 (LR χ 2: 25.73) | ||||
|---|---|---|---|---|---|---|
| Unadj HR (95% CI) | P | Adj HR (95% CI) | P | Adj HR (95% CI) | P | |
| Age (years) | 1.08 (1.02–1.15) | 0.01 | 1.07 (1.01–1.14) | 0.014 | 1.06 (1.00–1.13) | 0.04 |
| Gender (female) | 0.35 (0.15–0.81) | 0.02 | 0.24 (0.09–0.63) | 0.004 | 0.29 (0.11–0.73) | 0.009 |
| NYHA class | 2.69 (1.57–4.60) | <0.001 | 1.68 (0.95–2.96) | 0.07 | 1.61 (0.86–3.01) | 0.13 |
| LVEF, % | 0.97 (0.92–1.01) | 0.14 | — | — | — | — |
| RV‐basal diameter, mm | 1.02 (0.97–1.07) | 0.46 | — | — | — | — |
| RV end‐diastolic area, cm2 | 1.09 (1.05–1.14) | <0.001 | — | — | — | — |
| TR velocity, mm/s | 0.99 (0.98–1.01) | 0.60 | — | — | — | — |
| TAPSE, mm | 0.89 (0.79–1.01) | 0.06 | — | — | — | — |
| S′ wave TDI, cm/s | 0.95 (0.76–1.17) | 0.62 | — | — | — | — |
| RV‐FWLS, % | 1.16 (1.10–1.23) | 0.001 | — | — | — | — |
| Biplane VC, mm | 3.42 (1.30–9.01) | 0.013 | — | — | — | — |
| ERO, median (IQR), cm2 | 1.51 (1.06–2.12) | 0.02 | — | — | — | — |
| hsa‐miR‐15a‐5p | 0.21 (0.08–0.55) | 0.001 | 0.21 (0.06–0.64) | 0.007 | — | — |
| hsa‐miR‐101–3p | 0.20 (0.06–0.59) | 0.004 | — | — | — | — |
| hsa‐miR‐92a‐3p | 0.22 (0.09–0.54) | 0.001 | — | — | 0.27 (0.09–0.76) | 0.01 |
| hsa‐miR‐363‐3p | 0.34 (0.17–0.71) | 0.004 | — | — | — | — |
| hsa‐miR‐324‐3p | 0.31 (0.09–1.06) | 0.062 | — | — | — | — |
| hsa‐miR‐22‐3p | 0.23 (0.09–0.58) | 0.002 | — | — | — | — |
For univariate analyses, results are presented with unadjusted hazard ratios (unadj HR) with 95% confidence intervals (95% CI). Model 1: hsa‐miR‐15a‐5p, age, gender, NYHA class. Model 2: hsa‐miR‐92a‐3p, age, gender, NYHA class.
ERO, effective regurgitant orifice; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; RA, right atrium; RV, right ventricular; TR, tricuspid regurgitation.