Table 1.
Characteristics of NPC cases and controls in the Janus Serum Bank.
| Cases n (%) | Controls n (%) | p-value | |
|---|---|---|---|
| Incident cases and controls | 30 | 60 | |
| Analyzed blood samples | 48 | 60 | |
| Gender | 22 (73) | 44 (73) | 1 |
| Male | 8 (27) | 16 (27) | |
| Female | |||
| Smoking statusaNever | 5 (22) | 19 (34) | 0.56 |
| Former | 6 (26) | 13 (23) | |
| Current | 12 (52) | 24 (43) | |
| Alcohol use a | 2 (33) | 3 (13) | 0.24 |
| no current use | 4 (67) | 20 (87) | |
| current use | |||
| Case characteristics only | |||
| Cases with serial blood draws (N) | 10 | ||
| Median lead timeb in years for all cases (range) | 12 (−2, 41) | ||
| Median lead time in years for all incidentc cases (range) | 14 (3, 41) | ||
| Median age at diagnosis, (range) | 59 (29–83) | ||
| Median year of diagnosis (range) | 1998 (1983–2013) | ||
| Cases with valid tumor tissue results (N) | 21 | ||
| EBV positive by EBER-ISH | 12 (57) | ||
| HPV positive by HPV DNA and RNA | 4 (19) | ||
| EBV and HPV negative | 5 (24) | ||
| EBV and HPV positive | 0 (0) |
a
numbers may not add up to 100% due to missing data. Data on smoking was available for 23 cases and 56 controls. Data on alcohol use was available for 6 cases and 23 controls.
b
time between blood draw and diagnosis of 48 case sera, – 2 refers to two years post diagnosis.
c
incident cases include cases with a lead time of > 1 year.