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. Author manuscript; available in PMC: 2024 Jul 30.
Published in final edited form as: Cancer Epidemiol. 2022 Feb 1;77:102117. doi: 10.1016/j.canep.2022.102117

Table 1.

Characteristics of NPC cases and controls in the Janus Serum Bank.

Cases n (%) Controls n (%) p-value
Incident cases and controls 30 60
Analyzed blood samples 48 60
Gender 22 (73) 44 (73) 1
 Male 8 (27) 16 (27)
 Female
Smoking statusaNever 5 (22) 19 (34) 0.56
 Former 6 (26) 13 (23)
 Current 12 (52) 24 (43)
Alcohol use a 2 (33) 3 (13) 0.24
 no current use 4 (67) 20 (87)
 current use
Case characteristics only
Cases with serial blood draws (N) 10
Median lead timeb in years for all cases (range) 12 (−2, 41)
Median lead time in years for all incidentc cases (range) 14 (3, 41)
Median age at diagnosis, (range) 59 (29–83)
Median year of diagnosis (range) 1998 (1983–2013)
Cases with valid tumor tissue results (N) 21
 EBV positive by EBER-ISH 12 (57)
 HPV positive by HPV DNA and RNA 4 (19)
 EBV and HPV negative 5 (24)
 EBV and HPV positive 0 (0)
a

numbers may not add up to 100% due to missing data. Data on smoking was available for 23 cases and 56 controls. Data on alcohol use was available for 6 cases and 23 controls.

b

time between blood draw and diagnosis of 48 case sera, – 2 refers to two years post diagnosis.

c

incident cases include cases with a lead time of > 1 year.