Figure 5 -.
The anti-GnRH specific IgG subclass immune response. IgG subclass (IgG1, IgG2a) titers were measured in sera of mice (n=6) post vaccination on week 10. The IgG1/IgG2a ratio (ratios>1 and <1 indicate a Th2 and Th1 polarized response, respectively). A significant increase in titers was observed in pDNA nanoparticulate vaccine adjuvanted group (Alum and MF59). The p value was calculated (*p<0.05 significant, **p<0.01very significant, ***p<0.001 extremely significant) using one-way ANOVA with Tukey post hoc test. Data are expressed as mean ± SEM.