Table 3.

Common terminology used in REMAP trials

Term	Definition	Examples
Factor	The mutually exclusive interventions, categorised within domains, to which a patient can be randomised.	Pirfenidone Nintedanib New antifibrotic Control
Domain	A distinct category of mutually exclusive interventions called factors; patients can be randomised to receive a factor from a domain for which they are eligible.	Antifibrotic Immunomodulatory Senolytic Corticosteroids
Regimen	The collection of factors that a patient is randomised to across domains; patients receive one unique factor from each domain for which they are eligible.	Pirfenidone, mycophenolate, metformin and corticosteroid Nintedanib, control (no immunomodulation), metformin and control (no corticosteroid)
Stratum	Baseline disease characterisation that defines which domain(s) a patient is potentially eligible to participate in; strata can be used for stratified randomisation and strata-specific analyses.	IPF Non-IPF fILD

fILD, fibrotic interstitial lung disease; IPF, idiopathic pulmonary fibrosis; REMAP, Randomised Embedded Multifactorial Adaptive Platform.