Figure 4.

The impact of SP1 protein levels on allele-specific PLA2G2A gene expression across tissues. (a) Modeled PLA2G2A allele expression. In the upper panel, the ODE across an arbitrary range of SP1 level ([SP1]) (x-axis) was simulated to get the steady-state PLA2G2A expression level ([G2A]_ss) corresponding to the C and G alleles of rs11573156 (K_c and K_G, respectively). In the lower panel, $\Delta {\left[G2A\right]}_{ss}$ (y-axis) indicates the difference in the C and G allele PLA2G2A expression levels, which is box-plotted against [SP1] (x-axis) spanning 3 categories (with 5 bins in each category, as indicated in the top panel). The model parameters are $range\left(\left[SP1\right]\right)=\left[0,20\right],$ $k=1;d_{G2A}=0.01;n=2;K_C=1;K_G=2.$ (b) Empirical delta PLA2G2A allele expression. The differences (delta logTPM) of PLA2G2A transcript levels by genotype (C vs G allele at rs11573156) were calculated in each tissue based on the GTEx dataset and box-plotted against the 3 categories of SP1 protein levels (low, medium, and high) as in a. (c) Normalized effect size of rs11573156 in each tissue box-plotted against the 3 categories of SP1 protein levels as in a.