Table 1.

Candidate TFs associated with PLA2G2A gene expression determined by SNP2TFBS.

SNP (eQTL) rsID	Ref	Alt	Effect	eQTL tissues	Effect size	Matched TFs
rs12733637	A	G	down	Liver	−0.39	EBF1
				Prostate	−0.34
rs1891320	C	T	up	Liver	0.45	ZNF263
				Prostate	0.50
rs11573156	G	C	up	Liver	0.66	SP1
				Prostate	0.68
				Ovary	0.25
				Adipose-Visceral (Omentum)	0.17
				Stomach	0.19
				Heart-Atrial Appendage	0.15
				Heart-Left Ventricle	0.17
rs1796923	T	G	down	Skin-Sun Exposed (Lower leg)	−0.80	PPARG_RXRA
				Heart-Atrial Appendage	−0.51
				Skin-Not Sun Exposed (Suprapubic)	−0.65
				Esophagus-Muscularis	−0.62
				Thyroid	−0.40
				Heart-Left Ventricle	−0.48
				Adipose-Subcutaneous	−0.48
				Esophagus-Gastroesophageal Junction	−0.54
rs114156017	C	T	up	Liver	0.42	SREBF1 SREBF2
				Prostate	0.41
				Adipose-Visceral (Omentum)	0.18
				Heart-Atrial Appendage	0.16
rs149238894	G	A	up	Liver	0.40	GATA1
				Prostate	0.42
				Adipose-Visceral (Omentum)	0.18
				Heart-Atrial Appendage	0.15
rs139466428	TG	T	up	Prostate	0.38	FOXQ1
				Adipose-Visceral (Omentum)	0.15
				Esophagus-Muscularis	0.13

Ref , reference allele; Alt , alternative allele; Effect , the direction of the eQTL’s effect on PLA2G2A gene expression; “up” means the alternative allele upregulates PLA2G2A gene expression compared to the reference allele, and “down” means the alternative allele downregulates PLA2G2A gene expression compared to the reference allele.; eQTL tissues , tissue distribution of each eQTL; Effect size , the normalized effect size of each significant tissue-eQTL obtained from GTEx Portal, which was computed as the effect of the alternative allele relative to the reference allele in the human genome reference GRCh38/hg38; TF , transcription factor.