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ALDH2 variants display a reduced enzymatic activity and increased cellular ROS. (A) ALDH2 activity in transiently transfected NIH-3T3 cells. n = 5/group, *p < 0.01 by one-way ANOVA versus wild type ALDH2. (B) ROS levels measured by DFCA in cells treated 50 mM ethanol and compared with untreated cell, n = 6 or 7/group, ^P < 0.01 with unpaired two-tailed Student’s t-test relative to untreated
