Table 3.

Frequency of follow-up across the included cohort studies.

Study			Arm		Frequency of clinical observations	Frequency of laboratory investigations (not for diagnosis)		Frequency of laboratory diagnosis
Colombia: Diagnosis Cohort: Evaluation of the diagnostic accuracy and usefulness of rapid tests for early diagnosis of dengue			Outpatient and inpatient		3-5 days, 4-6 days, 5-7 days, 15-17 days (post illness onset)	3-5 days, 4-6 days, 5-7 days, 15-17 days (post illness onset)		3-5 days, 4-6 days, 5-7 days
Colombia: Prognosis Cohort: Immune mechanisms of pathogenesis in patients with dengue infection			Outpatient and inpatient		0-7 days, 2-6 weeks (Note: inpatients also provided clinical information every 48 hours during hospitalization.)	0-7 days, 2-6 weeks; (note: Inpatients also provided laboratory investigations every 48 hours during hospitalization.)		0-7 days
Colombia: Piedecuesta’s household-based dynamic cohort; identification of age groups to be prioritized for vaccination in a population of children and adolescents			Outpatient		Once per day (incident febrile cases)	Once per day (incident febrile cases)		0 days, 14 days (incident febrile cases)
Colombia: AEDESa Cohorts
	Identification of prognostic markers of severity in dengue	Outpatient		Once per day		Once per day	0 days, 14 days
	Validation of a clinical definition for dengue and evaluation of its usefulness to identify early conditions associated with hospitalization	Outpatient		Once per day		Once per day	0 days, 14 days
	Colombian multicentric study	Outpatient and inpatient		Once per day		0 days, 6 days (outpatient); once per day (inpatient)	0 days, 10 days
CDY15: Efficacy and safety of a new tetravalent dengue vaccine in healthy children and adolescents aged 9 years to 16 years in Latin America			Placebo		0-5 days, 14 days (incident febrile cases)	0-5 days, 14 days (incident febrile cases)		0-5 days, 14 days (incident febrile cases)
Nicaragua: Pediatric Dengue Hospital-Based Study			Outpatient		Once per day	Once per day		0 days, 1 day, 2 days; 14-28 days
Nicaragua: Pediatric Dengue Hospital-Based Study			Inpatient		More than once per day	Once per day		0 days, 1 day, 2 days, 14-28 days
Nicaragua: PDCSb			Follow-up		2-3 times per week	2-3 times per week		0 days, 14-21 days
Nicaragua: PDCS			Annual sample		N/Ac	Once per year		0 days
IDAMSd			Recruitment as outpatients; some proceeded to hospitalization		Once per day	Once per day		0 days, 3-6 days, 15 days
Cohort of symptomatic pregnant women			N/A		At enrollment, weekly telephone follow-up, and a second visit within 30 days after enrollment	N/A		0 days, 30 days

^aAEDES: Abordando Áreas Endémicas del Dengue Para el Estudio de su Severidad.

^bPDCS: Pediatric Dengue Cohort Study.

^cN/A: not applicable.

^dIDAMS: International Research Consortium on Dengue Risk Assessment, Management and Surveillance.