FIG. 4.

Comparison of the lysogeny replacement module from the virulent pac-site phage Sfi11 with that of the virulent cos-site phages Sfi19, Sfi18, and DT1. The predicted ORFs are annotated with their codon lengths. The 1-bp indels are indicated by vertical arrows, and the position of a second indel is marked by a solid arrowhead. The third indel corresponds to ORF 229 flanked by 68-bp direct repeats (open triangle). For comparison, the genome maps of the lysogeny modules from the pac-site S. thermophilus phages O1205 (top) and TPJ-34 (bottom) are shown. Regions of sequence similarity between the phages O1205 and Sfi11 on one side and DT1 and TPJ-34 on the other side are connected by dark shading. Regions of sequence diversity between the four virulent phages are connected by light shading. The solid triangle indicates one repeat in ORF 88 (Sfi18).