FIG. 1.

Amino acid sequence of the transmembrane (TM) anchor and carboxyl terminus of CMV gB, site-specific mutations, and potential sorting signals. (A) Hydrophobic sequence of the TM anchor (aa 751 to 771) (shaded sequence) and cytosolic domain (aa 772 to 906). Dileucine and Tyr-containing sorting motifs are boxed; the acidic cluster is underlined. P, CKII phosphorylation site. (B) Deletion and substitution mutations. Established internalization/recycling motifs that function as apical sorting signals are indicated by solid arrows; other sorting motifs for trafficking in the endocytic pathway are indicated by open arrows. Deleted sequences are indicated by dashed lines, and substitutions are indicated by shaded boxes. Modified from reference 55.