Fig. 5. Design of amyloid peptide traps.
a, Schematic illustration showing that designed amyloidogenic peptide binders (left, gray) can bind amyloidogenic sequences (yellow ribbon) that otherwise form amyloid fibrils through strand−strand interactions (right) and block fibril formation. AF2, AlphaFold2. b, Models of designs (middle column, designed binder in gray and target peptide in yellow) that bind amyloidogenic fragments (left column) from five different amyloid-forming proteins in BLI experiments (right column, legend in molar units).