Fig. 3.

A Heat map of mean values of the angiogenesis-related proteins significantly expressed between healthy controls and post-COVID-19 patients at short term (3-months) and long term (6–12 months). Green represents low expression, red moderate expression and black high expressed factors. B Pixel density of the angiogenesis-related proteins significantly expressed between healthy controls and post-COVID-19 patient. Ordinary one-way ANOVA followed by Tukey´s multiple comparisons test, ****P < 0.001. PAI-1 Plasminogen activator inhibitor 1, TIMP-1 tissue inhibitor of metalloproteinase 1, TIMP-2 Tissue inhibitor of metalloproteinase 2, MMP-8 matrix metalloproteinase-8, MMP-9 matrix metalloproteinase-9, PDGF-AA platelet-derived growth factor subunit A, PDGF-BB platelet-derived growth factor subunit B, CXCL4 platelet factor 4, PF4 platelet factor 4, IBP-1 Insulin-like growth factor-binding protein 1, IBP-2 insulin-like growth factor-binding protein 2, CXCL16 platelet factor 16, DPPIV dipeptidyl peptidase IV, CD26 Cluster of differentiation 26, EGF epidermal growth factor