Table 3.

(a) Summary of the evidence from quantitative research synthesis regarding the effect of BoNT-A treatment on muscle pain intensity, (b) Summary of the evidence from quantitative research synthesis regarding the effect of BoNT-A on mandibular movements, (c) Summary of the evidence from quantitative research synthesis regarding the effect of BoNT-A on adverse events

Green indicates a positive outcome in the synthesis. For treatment outcome that indicates an effect favoring BoNT-A in comparison to either placebo or other treatments of M-TMD. When it comes to adverse events that indicates that there are no reported adverse events or more than placebo

Orange indicates an uncertain outcome in the synthesis. For treatment outcome that indicates an effect that does not favor BoNT-A but can be similar to either placebo or other treatments of M-TMD. When it comes to adverse events it indicates mild adverse events

Red indicates an absence of effect outcome in the synthesis. For treatment outcome that indicates an effect that does not favor BoNT-A but instead favors either placebo or other treatments of M-TMD. When it comes to adverse events it indicates moderate to major/severe adverse events