| Evidence clearly indicates that BoNT-A has positive effects in the treatment of M-TMD but it is not superior to standard treatments. |
| BoNT-A treatment for M-TMDs could cause adverse effects on muscle and bony tissue of major importance that must be considered. |
| This umbrella review presents the highest level of evidence regarding BoNT-A treatment for M-TMDs, since it included only SRs with low risk of bias/high quality. |
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