Skip to main content
. 2024 Jul 30;15:6398. doi: 10.1038/s41467-024-50559-8

Fig. 7. Oxygen carrying capacity of the blood is reduced by aging.

Fig. 7

A Population average of locomotion onset and offset triggered average of brain oxygenation (∆HbO-HbR) responses in FL/HL and FC across different age groups. B Relationship between locomotion evoked change in ∆HbT and ∆HbO-HbR, 2-5 s after the onset of locomotion, across different age groups, in FL/HL, for 2month old: n = 7 (4 male and 3 female) and 18 month old: n = 4 (all male). Sex is shown with a black circle outline for males and a magenta circle outline for female mice. C Population average of ∆HbT (top) and ∆HbO-HbR (bottom) responses to inhalation of 100% oxygen in the FL/HL across different age groups. D As in (C) but for FC. E Group average of fractional changes of ∆HbT (left) and ∆HbO-HbR (right) in response to 100% oxygen in FL/HL across different age groups. For C-F, sample sizes include 2 month old: n = 4 (3 male and 1 female) and 18 month old: n = 4 (all male). Sex is shown with a black circle outline for males and a magenta circle outline for female mice. *p-value = 0.0097 (left), 0.0206 (right). F As in (E) but for FC. Solid lines and shaded areas in (A, C, D) denote mean ± SEM, respectively. Data are shown as mean ± SD in (E, F). Source data are provided as a Source Data file.