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. 2024 Jul 30;14:17515. doi: 10.1038/s41598-024-67371-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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JNJ-77242113 inhibited IL-23 receptor–mediated proximal signaling and downstream cytokine production in immune cells. IL-23–induced pSTAT3 (A) and (B) IL-12–induced pSTAT4 in human PBMCs. Concentration-dependent inhibition of IFNγ production in whole blood from (C) a healthy donor and (D) a donor with psoriasis. Panels (A) and (B) show data from one donor that is representative of 3 and 2 experiments, respectively. Panels (C) and (D) show data from one donor that is representative of data from 15 and 4 donors, respectively (see Table 1 for data summary). Each point represents the mean of duplicate values (A,B) or triplicate values (C,D); error bars denote SD. An arbitrary concentration value on the log(x) axis was used to plot mean values for the unstimulated or IL-23/IL-12–stimulated controls. IFN interferon, IL interleukin, MSD Meso Scale Discovery, PBMC peripheral blood mononuclear cells, pSTAT phosphorylated signal transducer and activator of transcription, SD standard deviation.